2F99

Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.

2F99 の概要

• エントリーDOI: 10.2210/pdb2f99/pdb
• 関連するPDBエントリー: 2F98
• 分子名称: Aklanonic Acid methyl Ester Cyclase, AknH, SULFATE ION, {3-[(1R,3S)-1,3-DIHYDROXYPENTYL]-4,5,9,10-TETRAHYDROXY-2-ANTHRYL}ACETATE, ... (4 entities in total)
• 機能のキーワード: anthracycline, polyketide cyclase, stereoselectivity, aklavinone, biosynthetic protein
• 由来する生物種: Streptomyces galilaeus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 74518.90

構造登録者

Kallio, P.,Sultana, A.,Neimi, J.,Mantsala, P.,Schneider, G. (登録日: 2005-12-05, 公開日: 2006-02-14, 最終更新日: 2023-08-30)

• 主引用文献: Kallio, P.,Sultana, A.,Niemi, J.,Schneider, G.; Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.; J.Mol.Biol., 357:210-220, 2006; PubMed: 16414075; DOI: 10.1016/j.jmb.2005.12.064

実験手法

X-RAY DIFFRACTION (1.9 Å)