2F8G

HIV-1 protease mutant I50V complexed with inhibitor TMC114

Summary for 2F8G

Entry DOI	10.2210/pdb2f8g/pdb
Related	2F80 2F81
Descriptor	POL POLYPROTEIN, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	hiv-1 protease-inhibitor complex, hydrolase
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587
Total number of polymer chains	2
Total formula weight	22307.06
Authors	Kovalevsky, A.Y.,Weber, I.T. (deposition date: 2005-12-02, release date: 2006-03-07, Last modification date: 2024-02-14)
Primary citation	Kovalevsky, A.Y.,Tie, Y.,Liu, F.,Boross, P.I.,Wang, Y.F.,Leshchenko, S.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M. J.Med.Chem., 49:1379-1387, 2006 Cited by PubMed: 16480273 DOI: 10.1021/jm050943c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.22 Å)

Structure validation