2F81
HIV-1 Protease mutant L90M complexed with inhibitor TMC114
Summary for 2F81
Entry DOI | 10.2210/pdb2f81/pdb |
Related | 2F80 2F8G |
Descriptor | POL POLYPROTEIN, SODIUM ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | hiv-1 protease-inhibitor complex, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587 |
Total number of polymer chains | 2 |
Total formula weight | 22343.18 |
Authors | Kovalevsky, A.Y.,Weber, I.T. (deposition date: 2005-12-01, release date: 2006-03-07, Last modification date: 2024-02-14) |
Primary citation | Kovalevsky, A.Y.,Tie, Y.,Liu, F.,Boross, P.I.,Wang, Y.F.,Leshchenko, S.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M. J.Med.Chem., 49:1379-1387, 2006 Cited by PubMed: 16480273DOI: 10.1021/jm050943c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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