2F53
Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity
Summary for 2F53
Entry DOI | 10.2210/pdb2f53/pdb |
Related | 2F54 |
Descriptor | HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ... (8 entities in total) |
Functional Keywords | t-cell receptor, cdr2, phage display, mutant, high affinity, ny-eso-1, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 Cytoplasm: P78358 |
Total number of polymer chains | 5 |
Total formula weight | 93672.14 |
Authors | Rizkallah, P.J.,Jakobsen, B.K.,Dunn, S.M.,Sami, M. (deposition date: 2005-11-25, release date: 2006-04-25, Last modification date: 2023-08-23) |
Primary citation | Dunn, S.M.,Rizkallah, P.J.,Baston, E.,Mahon, T.,Cameron, B.,Moysey, R.,Gao, F.,Sami, M.,Boulter, J.,Li, Y.,Jakobsen, B.K. Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci., 15:710-721, 2006 Cited by PubMed: 16600963DOI: 10.1110/ps.051936406 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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