2F4J
Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Summary for 2F4J
Entry DOI | 10.2210/pdb2f4j/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase ABL1, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE (3 entities in total) |
Functional Keywords | kinase, kinase inhibitor, abl, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33636.52 |
Authors | Young, M.A.,Shah, N.P.,Chao, L.H.,Zarrinkar, P.,Sawyers, P.,Kuriyan, J. (deposition date: 2005-11-23, release date: 2006-01-24, Last modification date: 2023-08-23) |
Primary citation | Young, M.A.,Shah, N.P.,Chao, L.H.,Seeliger, M.,Milanov, Z.V.,Biggs, W.H.,Treiber, D.K.,Patel, H.K.,Zarrinkar, P.P.,Lockhart, D.J.,Sawyers, C.L.,Kuriyan, J. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res., 66:1007-1014, 2006 Cited by PubMed: 16424036DOI: 10.1158/0008-5472.CAN-05-2788 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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