2F4J

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

2F4J の概要

• エントリーDOI: 10.2210/pdb2f4j/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase ABL1, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE (3 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, abl, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33636.52

構造登録者

Young, M.A.,Shah, N.P.,Chao, L.H.,Zarrinkar, P.,Sawyers, P.,Kuriyan, J. (登録日: 2005-11-23, 公開日: 2006-01-24, 最終更新日: 2023-08-23)

• 主引用文献: Young, M.A.,Shah, N.P.,Chao, L.H.,Seeliger, M.,Milanov, Z.V.,Biggs, W.H.,Treiber, D.K.,Patel, H.K.,Zarrinkar, P.P.,Lockhart, D.J.,Sawyers, C.L.,Kuriyan, J.; Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.; Cancer Res., 66:1007-1014, 2006; PubMed: 16424036; DOI: 10.1158/0008-5472.CAN-05-2788

実験手法

X-RAY DIFFRACTION (1.91 Å)