2F38
Crystal structure of prostaglandin F synathase containing bimatoprost
Summary for 2F38
Entry DOI | 10.2210/pdb2f38/pdb |
Descriptor | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE, ... (4 entities in total) |
Functional Keywords | prostaglandin f synthase, akr1c3, pgf2alpha fromation, pgh2, bimatoprost, catalytic mechanism, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P42330 |
Total number of polymer chains | 1 |
Total formula weight | 38055.19 |
Authors | Komoto, J.,Yamada, T.,Watanabe, K.,Woodward, D.F.,Takusagawa, F. (deposition date: 2005-11-18, release date: 2006-10-31, Last modification date: 2023-08-23) |
Primary citation | Komoto, J.,Yamada, T.,Watanabe, K.,Woodward, D.F.,Takusagawa, F. Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost. Biochemistry, 45:1987-1996, 2006 Cited by PubMed: 16475787DOI: 10.1021/bi051861t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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