2EWP
Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182
Summary for 2EWP
Entry DOI | 10.2210/pdb2ewp/pdb |
Descriptor | Estrogen-related receptor gamma, (Z)-4-(1-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-HYDROXY-2-PHENYLPENT-1-ENYL)PHENOL (3 entities in total) |
Functional Keywords | tamoxifen, err, estrogen related receptor, orphan receptor, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P62508 |
Total number of polymer chains | 5 |
Total formula weight | 130376.81 |
Authors | Nolte, R.T. (deposition date: 2005-11-04, release date: 2006-05-09, Last modification date: 2024-04-03) |
Primary citation | Chao, E.Y.,Collins, J.L.,Gaillard, S.,Miller, A.B.,Wang, L.,Orband-Miller, L.A.,Nolte, R.T.,McDonnell, D.P.,Willson, T.M.,Zuercher, W.J. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg.Med.Chem.Lett., 16:821-824, 2006 Cited by PubMed: 16307879DOI: 10.1016/j.bmcl.2005.11.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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