2ETM

Crystal Structure of Focal Adhesion Kinase Domain Complexed with 7H-Pyrrolo [2,3-d] pyrimidine Derivative

Summary for 2ETM

• Entry DOI: 10.2210/pdb2etm/pdb
• Descriptor: Focal adhesion kinase 1, 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE (3 entities in total)
• Functional Keywords: kinase catalytic domain, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell junction, focal adhesion: Q05397
• Total number of polymer chains: 2
• Total formula weight: 65217.13

Authors

Lee, C.C. (deposition date: 2005-10-27, release date: 2006-10-10, Last modification date: 2023-08-23)

• Primary citation: Andersen, C.B.,Ng, K.,Vu, C.,Ficarro, S.,Choi, H.-S.,Gray, N.,He, Y.,Lee, C.C.; Crystal Structure of Focal Adhesion Kinase Domain Complexed with ATP and novel 7H-Pyrrolo [2,3-d] pyrimidine scaffolds; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)