2ESM
Crystal Structure of ROCK 1 bound to fasudil
Summary for 2ESM
Entry DOI | 10.2210/pdb2esm/pdb |
Related | 2ERZ 2ETK 2ETO 2ETR |
Descriptor | Rho-associated protein kinase 1, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (3 entities in total) |
Functional Keywords | kinase, dimer, dimerization, myosin, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13464 |
Total number of polymer chains | 2 |
Total formula weight | 96607.31 |
Authors | Jacobs, M. (deposition date: 2005-10-26, release date: 2005-11-08, Last modification date: 2023-08-23) |
Primary citation | Jacobs, M.,Hayakawa, K.,Swenson, L.,Bellon, S.,Fleming, M.,Taslimi, P.,Doran, J. The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity. J.Biol.Chem., 281:260-268, 2006 Cited by PubMed: 16249185DOI: 10.1074/jbc.M508847200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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