2ESM
Crystal Structure of ROCK 1 bound to fasudil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Rho-associated protein kinase 1 | polymer | 415 | 48012.3 | 2 | UniProt (Q13464) Pfam (PF00069) In PDB | Homo sapiens (human) | Rho-associated, coiled-coil containing protein kinase 1, p160 ROCK-1, p160ROCK |
| 2 | A, B | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE | non-polymer | 291.4 | 2 | Chemie (M77) | |||
| 3 | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence modifications
A, B: 6 - 415 (UniProt: Q13464)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ser 2 | - | cloning artifact |
| Leu 3 | - | cloning artifact |
| His 4 | - | cloning artifact |
| Met 5 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96024.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 582.7 | |
| All* | Total formula weight | 96607.3 |
