2EI8
FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-chloroindol-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine
Summary for 2EI8
Entry DOI | 10.2210/pdb2ei8/pdb |
Related | 1v3x 1wu1 2EI6 2EI7 2d1j |
Descriptor | Coagulation factor X, heavy chain, Coagulation factor X, light chain, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 32816.77 |
Authors | Suzuki, M. (deposition date: 2007-03-12, release date: 2008-03-18, Last modification date: 2023-10-25) |
Primary citation | Nagata, T.,Yoshino, T.,Haginoya, N.,Yoshikawa, K.,Nagamochi, M.,Kobayashi, S.,Komoriya, S.,Yokomizo, A.,Muto, R.,Yamaguchi, K.,Osanai, K.,Suzuki, M.,Kanno, H. Discovery of N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A Novel, Potent and Orally Active Direct Inhibitor of Factor Xa To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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