2EI8

FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-chloroindol-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

Summary for 2EI8

Related2EI6 2EI7 1v3x 1wu1 2d1j
DescriptorCoagulation factor X, heavy chain, Coagulation factor X, light chain, CALCIUM ION, ... (5 entities in total)
Functional Keywordsglycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
Biological sourceHomo sapiens (human)
Cellular locationSecreted P00742 P00742
Total number of polymer chains2
Total molecular weight32816.77
Authors
Suzuki, M. (deposition date: 2007-03-12, release date: 2008-03-18, Last modification date: 2011-07-13)
Primary citation
Nagata, T.,Yoshino, T.,Haginoya, N.,Yoshikawa, K.,Nagamochi, M.,Kobayashi, S.,Komoriya, S.,Yokomizo, A.,Muto, R.,Yamaguchi, K.,Osanai, K.,Suzuki, M.,Kanno, H.
Discovery of N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A Novel, Potent and Orally Active Direct Inhibitor of Factor Xa
To be Published,
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers402.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution