2EI8

FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-chloroindol-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

Summary for 2EI8

• Entry DOI: 10.2210/pdb2ei8/pdb
• Related: 1v3x 1wu1 2EI6 2EI7 2d1j
• Descriptor: Coagulation factor X, heavy chain, Coagulation factor X, light chain, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32816.77

Authors

Suzuki, M. (deposition date: 2007-03-12, release date: 2008-03-18, Last modification date: 2023-10-25)

• Primary citation: Nagata, T.,Yoshino, T.,Haginoya, N.,Yoshikawa, K.,Nagamochi, M.,Kobayashi, S.,Komoriya, S.,Yokomizo, A.,Muto, R.,Yamaguchi, K.,Osanai, K.,Suzuki, M.,Kanno, H.; Discovery of N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A Novel, Potent and Orally Active Direct Inhibitor of Factor Xa; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)