2EA0
Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli in complex with AP-site containing DNA substrate
Summary for 2EA0
Entry DOI | 10.2210/pdb2ea0/pdb |
Related | 2OPF 2OQ4 |
Descriptor | 5'-D(P*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3', 5'-D(P*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ... (7 entities in total) |
Functional Keywords | endonuclease viii, oxidative damage, dna repair, base excision, covalent intermediate, reaction mechanism, hydrolase-dna complex, hydrolase/dna |
Biological source | Escherichia coli |
Total number of polymer chains | 3 |
Total formula weight | 37656.53 |
Authors | Golan, G.,Zharov, D.O.,Grollman, A.P.,Shoham, G. (deposition date: 2007-01-29, release date: 2008-02-26, Last modification date: 2023-10-25) |
Primary citation | Golan, G.,Zharkov, D.O.,Grollman, A.P.,Shoham, G. Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrate and mutations of critical residues To be Published, |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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