2E98

E. coli undecaprenyl pyrophosphate synthase in complex with BPH-629

Summary for 2E98

• Entry DOI: 10.2210/pdb2e98/pdb
• Related: 1X06 1X07 1X08 1X09 2E99 2E9A 2E9C 2E9D
• Descriptor: Undecaprenyl pyrophosphate synthetase, [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID (3 entities in total)
• Functional Keywords: cell wall, prenyltransferase, farnesyl pyrophosphate, bisphosphonate, antibiotic, transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 60100.35

Authors

Guo, R.T.,Ko, T.P.,Cao, R.,Liang, P.H.,Oldfield, E.,Wang, A.H.J. (deposition date: 2007-01-24, release date: 2007-06-12, Last modification date: 2023-10-25)

• Primary citation: Guo, R.T.,Cao, R.,Liang, P.H.,Ko, T.P.,Chang, T.H.,Hudock, M.P.,Jeng, W.Y.,Chen, C.K.M.,Zhang, Y.,Song, Y.,Kuo, C.J.,Yin, F.,Oldfield, E.,Wang, A.H.J.; Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases; Proc.Natl.Acad.Sci.Usa, 104:10022-10027, 2007; PubMed: 17535895; DOI: 10.1073/pnas.0702254104

Experimental method

X-RAY DIFFRACTION (1.9 Å)