2E7A
TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
Summary for 2E7A
Entry DOI | 10.2210/pdb2e7a/pdb |
Related | 1TNF 1TNR |
Descriptor | Tumor necrosis factor (2 entities in total) |
Functional Keywords | tumor necrosis factor, trimer, antagonistic activity, tnfr1 specific, phage display system, cytokine |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375 |
Total number of polymer chains | 3 |
Total formula weight | 51898.04 |
Authors | Mukai, Y.,Yamagata, Y.,Tsutsumi, Y. (deposition date: 2007-01-09, release date: 2007-11-13, Last modification date: 2023-10-25) |
Primary citation | Shibata, H.,Yoshioka, Y.,Ohkawa, A.,Minowa, K.,Mukai, Y.,Abe, Y.,Taniai, M.,Nomura, T.,Kayamuro, H.,Nabeshi, H.,Sugita, T.,Imai, S.,Nagano, K.,Yoshikawa, T.,Fujita, T.,Nakagawa, S.,Yamamoto, A.,Ohta, T.,Hayakawa, T.,Mayumi, T.,Vandenabeele, P.,Aggarwal, B.B.,Nakamura, T.,Yamagata, Y.,Tsunoda, S.,Kamada, H.,Tsutsumi, Y. Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist J.Biol.Chem., 283:998-1007, 2008 Cited by PubMed: 18003610DOI: 10.1074/jbc.M707933200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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