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2E7A

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity

Summary for 2E7A
Entry DOI10.2210/pdb2e7a/pdb
Related1TNF 1TNR
DescriptorTumor necrosis factor (2 entities in total)
Functional Keywordstumor necrosis factor, trimer, antagonistic activity, tnfr1 specific, phage display system, cytokine
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375
Total number of polymer chains3
Total formula weight51898.04
Authors
Mukai, Y.,Yamagata, Y.,Tsutsumi, Y. (deposition date: 2007-01-09, release date: 2007-11-13, Last modification date: 2023-10-25)
Primary citationShibata, H.,Yoshioka, Y.,Ohkawa, A.,Minowa, K.,Mukai, Y.,Abe, Y.,Taniai, M.,Nomura, T.,Kayamuro, H.,Nabeshi, H.,Sugita, T.,Imai, S.,Nagano, K.,Yoshikawa, T.,Fujita, T.,Nakagawa, S.,Yamamoto, A.,Ohta, T.,Hayakawa, T.,Mayumi, T.,Vandenabeele, P.,Aggarwal, B.B.,Nakamura, T.,Yamagata, Y.,Tsunoda, S.,Kamada, H.,Tsutsumi, Y.
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
J.Biol.Chem., 283:998-1007, 2008
Cited by
PubMed: 18003610
DOI: 10.1074/jbc.M707933200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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数据于2024-03-27公开中

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