2E56

Crystal structure of human MD-2

2E56 の概要

• エントリーDOI: 10.2210/pdb2e56/pdb
• 関連するPDBエントリー: 2E59
• 分子名称: Lymphocyte antigen 96, 2-acetamido-2-deoxy-beta-D-glucopyranose, MYRISTIC ACID, ... (4 entities in total)
• 機能のキーワード: innate immunity, lipid-binding, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17713.66

構造登録者

Ohto, U.,Satow, Y. (登録日: 2006-12-19, 公開日: 2007-06-26, 最終更新日: 2024-11-06)

主引用文献

Ohto, U.,Fukase, K.,Miyake, K.,Satow, Y.
Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.
Science, 316:1632-1634, 2007

PubMed Abstract: Endotoxic lipopolysaccharide (LPS) with potent immunostimulatory activity is recognized by the receptor complex of MD-2 and Toll-like receptor 4. Crystal structures of human MD-2 and its complex with the antiendotoxic tetra-acylated lipid A core of LPS have been determined at 2.0 and 2.2 angstrom resolutions, respectively. MD-2 shows a deep hydrophobic cavity sandwiched by two beta sheets, in which four acyl chains of the ligand are fully confined. The phosphorylated glucosamine moieties are located at the entrance to the cavity. These structures suggest that MD-2 plays a principal role in endotoxin recognition and provide a basis for antiseptic drug development.

PubMed: 17569869
DOI: 10.1126/science.1139111

実験手法

X-RAY DIFFRACTION (2 Å)