2E41

Crystal Structure Of Biotin Protein Ligase From Pyrococcus Horikoshii Complexed with the Reaction Product Analog Biotinol-5'-AMP, Mutations R48A and K111A

2E41 の概要

• エントリーDOI: 10.2210/pdb2e41/pdb
• 関連するPDBエントリー: 1WQW 2E3Y
• 分子名称: biotin--[acetyl-CoA-carboxylase] ligase, ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE (3 entities in total)
• 機能のキーワード: biotin biosynthesis, dimer, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, ligase
• 由来する生物種: Pyrococcus horikoshii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53037.68

構造登録者

Bagautdinov, B.,Matsuura, Y.,Bagautdinova, S.,Kunishima, N.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2006-12-01, 公開日: 2007-06-05, 最終更新日: 2023-10-25)

• 主引用文献: Bagautdinov, B.,Matsuura, Y.,Bagautdinova, S.,Kunishima, N.; Protein biotinylation visualized by a complex structure of biotin protein ligase with a substrate; J.Biol.Chem., 283:14739-14750, 2008; PubMed: 18372281; DOI: 10.1074/jbc.M709116200

実験手法

X-RAY DIFFRACTION (1.75 Å)