2DEB

Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221

Summary for 2DEB

Entry DOI	10.2210/pdb2deb/pdb
Related	2fw3 2fyo
Descriptor	Carnitine O-palmitoyltransferase II, mitochondrial, COENZYME A, PALMITIC ACID, ... (5 entities in total)
Functional Keywords	central six-stranded beta-sheet, transferase
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	2
Total formula weight	150597.99
Authors	Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. (deposition date: 2006-02-10, release date: 2007-02-10, Last modification date: 2024-10-30)
Primary citation	Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment Structure, 14:713-723, 2006 Cited by PubMed Abstract: Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association. PubMed: 16615901 DOI: 10.1016/j.str.2006.01.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation