2DEB

Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221

2DEB の概要

• エントリーDOI: 10.2210/pdb2deb/pdb
• 関連するPDBエントリー: 2fw3 2fyo
• 分子名称: Carnitine O-palmitoyltransferase II, mitochondrial, COENZYME A, PALMITIC ACID, ... (5 entities in total)
• 機能のキーワード: central six-stranded beta-sheet, transferase
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 150597.99

構造登録者

Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. (登録日: 2006-02-10, 公開日: 2007-02-10, 最終更新日: 2024-10-30)

主引用文献

Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M.
The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment
Structure, 14:713-723, 2006

PubMed Abstract: Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.

PubMed: 16615901
DOI: 10.1016/j.str.2006.01.008

実験手法

X-RAY DIFFRACTION (1.6 Å)