2D41

X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with non-nucleoside inhibitor

Summary for 2D41

• Entry DOI: 10.2210/pdb2d41/pdb
• Related: 2D3U 2D3Z
• Descriptor: polyprotein, 5'-ACETYL-4-{[(2,4-DIMETHYLPHENYL)SULFONYL]AMINO}-2,2'-BITHIOPHENE-5-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: hepatitis c virus, rna polymerase, enzyme inhibition, transferase
• Biological source: Hepatitis C virus
• Total number of polymer chains: 2
• Total formula weight: 128291.29

Authors

Biswal, B.K.,Wang, M.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Bedard, J.,James, M.N.G. (deposition date: 2005-10-05, release date: 2006-08-01, Last modification date: 2011-07-13)

• Primary citation: Biswal, B.K.,Wang, M.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Bedard, J.,James, M.N.G.; Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition; J.Mol.Biol., 361:33-45, 2006; PubMed: 16828488; DOI: 10.1016/j.jmb.2006.05.074

Experimental method

X-RAY DIFFRACTION (2.1 Å)