2CXV
Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-Derived betaLactone: Selective Crystallization and High-resolution Structure of the His-102 Adduct
2CXV の概要
エントリーDOI | 10.2210/pdb2cxv/pdb |
関連するPDBエントリー | 1HAV 1QA7 2A4O |
分子名称 | Probable protein P3C, N-[(BENZYLOXY)CARBONYL]-L-ALANINE (3 entities in total) |
機能のキーワード | hepatitis a, picornavirus, 3c, cysteine protease, inhibitor, beta-lactone, hydrolase |
由来する生物種 | Human hepatitis A virus Hu/Northern Africa/MBB/1978 |
細胞内の位置 | Protein VP2: Virion (By similarity). Protein VP3: Virion (By similarity). Protein VP1: Virion (By similarity). Protein VP1-2A: Virion (By similarity). Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3ABC: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3AB: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P13901 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 24343.00 |
構造登録者 | Yin, J.,Bergmann, E.M.,Cherney, M.M.,Lall, M.S.,Jain, R.P.,Vederas, J.C.,James, M.N.G. (登録日: 2005-07-01, 公開日: 2005-12-27, 最終更新日: 2023-10-25) |
主引用文献 | Yin, J.,Bergmann, E.M.,Cherney, M.M.,Lall, M.S.,Jain, R.P.,Vederas, J.C.,James, M.N.G. Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-derived beta-Lactone: Selective Crystallization and Formation of a Functional Catalytic Triad in the Active Site J.MOL.BIOL., 354:854-871, 2005 Cited by PubMed: 16288920DOI: 10.1016/j.jmb.2005.09.074 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.4 Å) |
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