2CW0

Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution

Summary for 2CW0

• Entry DOI: 10.2210/pdb2cw0/pdb
• Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (7 entities in total)
• Functional Keywords: rna polymerase holoenzyme, transcription, bent-bridge helix, transferase
• Biological source: Thermus thermophilus; More
• Total number of polymer chains: 12
• Total formula weight: 853581.22

Authors

Tuske, S.,Sarafianos, S.G.,Wang, X.,Hudson, B.,Sineva, E.,Mukhopadhyay, J.,Birktoft, J.J.,Leroy, O.,Ismail, S.,Clark Jr., A.D.,Dharia, C.,Napoli, A.,Laptenko, O.,Lee, J.,Borukhov, S.,Ebright, R.H.,Arnold, E. (deposition date: 2005-06-15, release date: 2005-09-20, Last modification date: 2023-10-25)

• Primary citation: Tuske, S.,Sarafianos, S.G.,Wang, X.,Hudson, B.,Sineva, E.,Mukhopadhyay, J.,Birktoft, J.J.,Leroy, O.,Ismail, S.,Clark Jr., A.D.,Dharia, C.,Napoli, A.,Laptenko, O.,Lee, J.,Borukhov, S.,Ebright, R.H.,Arnold, E.; Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation; Cell(Cambridge,Mass.), 122:541-552, 2005; PubMed: 16122422; DOI: 10.1016/j.cell.2005.07.017

Experimental method

X-RAY DIFFRACTION (3.3 Å)