2COJ
Crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with gabapentin
Summary for 2COJ
Entry DOI | 10.2210/pdb2coj/pdb |
Related | 2COG 2COI |
Descriptor | branched chain aminotransferase 1, cytosolic, PYRIDOXAL-5'-PHOSPHATE, [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID, ... (5 entities in total) |
Functional Keywords | plp-dependent enzyme, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P54687 |
Total number of polymer chains | 2 |
Total formula weight | 87019.26 |
Authors | Goto, M. (deposition date: 2005-05-17, release date: 2005-08-30, Last modification date: 2021-11-10) |
Primary citation | Goto, M.,Miyahara, I.,Hirotsu, K.,Conway, M.,Yennawar, N.,Islam, M.M.,Hutson, S.M. Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin J.Biol.Chem., 280:37246-37256, 2005 Cited by PubMed: 16141215DOI: 10.1074/jbc.M506486200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report