2COG

Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with 4-methylvalerate

Summary for 2COG

• Entry DOI: 10.2210/pdb2cog/pdb
• Related: 2COI 2COJ
• Descriptor: branched chain aminotransferase 1, cytosolic, PYRIDOXAL-5'-PHOSPHATE, 4-METHYL VALERIC ACID, ... (5 entities in total)
• Functional Keywords: plp-dependent enzyme, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P54687
• Total number of polymer chains: 2
• Total formula weight: 86909.10

Authors

Goto, M. (deposition date: 2005-05-17, release date: 2005-08-30, Last modification date: 2021-11-10)

• Primary citation: Goto, M.,Miyahara, I.,Hirotsu, K.,Conway, M.,Yennawar, N.,Islam, M.M.,Hutson, S.M.; Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin; J.Biol.Chem., 280:37246-37256, 2005; PubMed: 16141215; DOI: 10.1074/jbc.M506486200

Experimental method

X-RAY DIFFRACTION (2.1 Å)