2CHW

A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39

Summary for 2CHW

Entry DOI	10.2210/pdb2chw/pdb
Related	1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHX 2CHZ
Descriptor	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE (3 entities in total)
Functional Keywords	transferase/inhibitor, complex transferase-inhibitor, phosphoinositide, kinase, lipid, inhibitor, 3-kinase, signaling, quinazolinone, transferase, transferase-inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	111207.07
Authors	Knight, Z.A.,Gonzalez, B.,Feldman, M.E.,Zunder, E.R.,Goldenberg, D.D.,Williams, O.,Loewith, R.,Stokoe, D.,Balla, A.,Toth, B.,Balla, T.,Weiss, W.A.,Williams, R.L.,Shokat, K.M. (deposition date: 2006-03-16, release date: 2006-05-22, Last modification date: 2023-12-13)
Primary citation	Knight, Z.A.,Gonzalez, B.,Feldman, M.E.,Zunder, E.R.,Goldenberg, D.D.,Williams, O.,Loewith, R.,Stokoe, D.,Balla, A.,Toth, B.,Balla, T.,Weiss, W.A.,Williams, R.L.,Shokat, K.M. A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling Cell(Cambridge,Mass.), 125:733-, 2006 Cited by PubMed: 16647110 DOI: 10.1016/J.CELL.2006.03.035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation