2CF9
Complex of recombinant human thrombin with an inhibitor
Summary for 2CF9
Entry DOI | 10.2210/pdb2cf9/pdb |
Related | 2CF8 |
Related PRD ID | PRD_000481 |
Descriptor | THROMBIN HEAVY CHAIN, HIRUDIN IIIA, THROMBIN LIGHT CHAIN, ... (7 entities in total) |
Functional Keywords | hydrolase/inhibitor, acute phase, blood coagulation, calcium-binding, glycoprotein, hydolase, serine protease, serine protease inhibitor complex, complex hydrolase-inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28508 |
Total number of polymer chains | 3 |
Total formula weight | 34803.87 |
Authors | Schweizer, E.,Hoffmann-Roeder, A.,Olsen, J.A.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. (deposition date: 2006-02-17, release date: 2006-06-14, Last modification date: 2023-12-13) |
Primary citation | Schweizer, E.,Hoffmann-Roeder, A.,Olsen, J.A.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. Multipolar Interactions in the D Pocket of Thrombin: Large Differences between Tricyclic Imide and Lactam Inhibitors. Org.Biomol.Chem., 4:2364-, 2006 Cited by PubMed: 16763681DOI: 10.1039/B602585D PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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