Functional Information from GO Data
| Chain | GOid | namespace | contents |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0005509 | molecular_function | calcium ion binding |
| H | 0006508 | biological_process | proteolysis |
| H | 0007596 | biological_process | blood coagulation |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005576 | cellular_component | extracellular region |
| L | 0006508 | biological_process | proteolysis |
| L | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 348 H 1247 |
| Chain | Residue |
| H | HIS57 |
| H | GLY219 |
| H | GLY226 |
| H | HOH2206 |
| H | HOH2378 |
| H | HOH2400 |
| H | TYR60 |
| H | ASN98 |
| H | LEU99 |
| H | ASP189 |
| H | ALA190 |
| H | SER214 |
| H | TRP215 |
| H | GLY216 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA H 1248 |
| Chain | Residue |
| H | ARG221 |
| H | LYS224 |
| H | HOH2315 |
| H | HOH2316 |
| H | HOH2366 |
| H | HOH2375 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA H 1249 |
| Chain | Residue |
| H | LYS169 |
| H | THR172 |
| H | PHE204 |
| H | HOH2291 |
| H | HOH2302 |
| H | HOH2347 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR CHAIN I OF HIRUDIN IIIA |
| Chain | Residue |
| H | PHE34 |
| H | GLN38 |
| H | LEU65 |
| H | ARG73 |
| H | THR74 |
| H | ARG75 |
| H | TYR76 |
| H | HOH2142 |
| H | HOH2155 |
| H | HOH2268 |
| I | HOH2001 |
| I | HOH2002 |
| I | HOH2003 |
| I | HOH2004 |
| I | HOH2005 |
| I | HOH2006 |
| I | HOH2007 |
| I | HOH2008 |
| I | HOH2009 |
| I | HOH2011 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| H | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| H | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000250 |
| Chain | Residue | Details |
| I | TYR9 | |
| H | ASP102 | |
| H | SER195 | |
| Chain | Residue | Details |
| H | ASN60 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP102 | |
| H | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | SER195 | |
| H | GLY196 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | SER195 | |
| H | GLY193 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP102 | |
| H | SER195 | |
| H | GLY193 | |
| H | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP102 | |
| H | SER195 | |
| H | HIS57 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP102 | |
| H | SER195 | |
| H | HIS57 | |
| H | GLY196 | |
