2CF8

Complex of recombinant human thrombin with an inhibitor

2CF8 の概要

• エントリーDOI: 10.2210/pdb2cf8/pdb
• 関連するPDBエントリー: 2CF9
• 関連するBIRD辞書のPRD_ID: PRD_000481
• 分子名称: THROMBIN HEAVY CHAIN, HIRUDIN IIIA, THROMBIN LIGHT CHAIN, ... (7 entities in total)
• 機能のキーワード: hydrolase/inhibitor, acute phase, blood coagulation, calcium-binding, glycoprotein, hydolase, serine protease, serine protease inhibitor complex, complex hydrolase-inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28508
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 34808.29

構造登録者

Schweizer, E.,Hoffmann-Roeder, A.,Olsen, J.A.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F. (登録日: 2006-02-17, 公開日: 2006-06-14, 最終更新日: 2023-12-13)

• 主引用文献: Schweizer, E.,Hoffmann-Roeder, A.,Olsen, J.A.,Seiler, P.,Obst-Sander, U.,Wagner, B.,Kansy, M.,Banner, D.W.,Diederich, F.; Multipolar Interactions in the D Pocket of Thrombin: Large Differences between Tricyclic Imide and Lactam Inhibitors.; Org.Biomol.Chem., 4:2364-, 2006; PubMed: 16763681; DOI: 10.1039/B602585D

実験手法

X-RAY DIFFRACTION (1.3 Å)