2CEJ
P1' Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold
Summary for 2CEJ
Entry DOI | 10.2210/pdb2cej/pdb |
Related | 1WBK 1WBM 2CEM 2CEN |
Descriptor | POL PROTEIN, 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE (3 entities in total) |
Functional Keywords | hiv-1, protease, inhibitor, aspartyl protease, hydrolase |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS 1 |
Total number of polymer chains | 2 |
Total formula weight | 22289.13 |
Authors | Ginman, N.,Ekegren, J.K.,Johansson, A.,Wallberg, H.,Larhed, M.,Samuelsson, B.,Hallberg, A.,Unge, T. (deposition date: 2006-02-07, release date: 2007-02-13, Last modification date: 2023-12-13) |
Primary citation | Ekegren, J.K.,Ginman, N.,Johansson, A.,Wallberg, H.,Larhed, M.,Samuelsson, B.,Unge, T.,Hallberg, A. Microwave-Accelerated Synthesis of P1'-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold J.Med.Chem., 49:1828-, 2006 Cited by PubMed: 16509598DOI: 10.1021/JM051239Z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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