2CAS
THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE
Summary for 2CAS
| Entry DOI | 10.2210/pdb2cas/pdb |
| Descriptor | CANINE PARVOVIRUS EMPTY CAPSID (STRAIN D) VIRAL PROTEIN 2 (2 entities in total) |
| Functional Keywords | parvovirus coat protein, icosahedral virus, virus |
| Biological source | Canine parvovirus |
| Cellular location | Virion (By similarity): Q11213 |
| Total number of polymer chains | 1 |
| Total formula weight | 61562.37 |
| Authors | Wu, H.,Rossmann, M.G. (deposition date: 1993-08-24, release date: 1994-01-31, Last modification date: 2024-10-23) |
| Primary citation | Wu, H.,Rossmann, M.G. The canine parvovirus empty capsid structure. J.Mol.Biol., 233:231-244, 1993 Cited by PubMed Abstract: The structure of empty canine parvovirus capsids shows that residues 37 to the carboxy-terminal residue 584 (VP2 numbering) are ordered in each of the 60 subunits. The central structural motif of each subunit is the eight-stranded antiparallel beta-barrel that has been found in many other virus structures. Five beta-hairpin turns form a beta-cylindrical structure at each icosahedral 5-fold axis. The N-terminal glycine-rich sequence can be accommodated within this cylinder without excessive steric hindrance, consistent with the electron density distribution. By far the largest conformational differences between the full and empty virus were found in the region where some ordered DNA has been observed to bind in canine parvovirus full particles. Extensive interactions among 3-fold related subunits indicate that a trimeric subunit might be a viral assembly intermediate. PubMed: 8377200DOI: 10.1006/jmbi.1993.1502 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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