2C8W

thrombin inhibitors

2C8W の概要

• エントリーDOI: 10.2210/pdb2c8w/pdb
• 関連するPDBエントリー: 2C8X 2C8Y 2C8Z 2C90 2C93
• 分子名称: THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN VARIANT-2, ... (6 entities in total)
• 機能のキーワード: protease, blood coagulation, thrombin, acute phase, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, plasma, serine protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P09945
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35994.38

構造登録者

Howard, N.,Abell, C.,Blakemore, W.,Carr, R.,Chessari, G.,Congreve, M.,Howard, S.,Jhoti, H.,Murray, C.W.,Seavers, L.C.A.,van Montfort, R.L.M. (登録日: 2005-12-08, 公開日: 2006-07-04, 最終更新日: 2023-12-13)

• 主引用文献: Howard, N.,Abell, C.,Blakemore, W.,Chessari, G.,Congreve, M.,Howard, S.,Jhoti, H.,Murray, C.W.,Seavers, L.C.A.,Van Montfort, R.L.M.; Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors; J.Med.Chem., 49:1346-, 2006; PubMed: 16480269; DOI: 10.1021/JM050850V

実験手法

X-RAY DIFFRACTION (1.96 Å)