2C8W
thrombin inhibitors
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0007596 | biological_process | blood coagulation |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 1248 |
| Chain | Residue |
| B | ARG221 |
| B | LYS224 |
| B | HOH2277 |
| B | HOH2279 |
| B | HOH2295 |
| B | HOH2318 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE C7M B 1249 |
| Chain | Residue |
| B | TRP96 |
| B | GLU97 |
| B | ASN98 |
| B | LEU99 |
| B | ASP189 |
| B | ALA190 |
| B | CYS191 |
| B | GLU192 |
| B | SER195 |
| B | VAL213 |
| B | SER214 |
| B | TRP215 |
| B | GLY216 |
| B | GLU217 |
| B | GLY219 |
| B | CYS220 |
| B | GLY226 |
| B | PHE227 |
| B | HOH2345 |
| B | HOH2346 |
| B | HOH2348 |
| B | HOH2350 |
| B | HIS57 |
| B | TYR60 |
| B | TRP60 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 |
| Chain | Residue |
| B | PHE34 |
| B | GLN38 |
| B | LEU65 |
| B | ARG67 |
| B | ARG73 |
| B | THR74 |
| B | ARG75 |
| B | TYR76 |
| B | GLU80 |
| B | LYS81 |
| B | ILE82 |
| B | MET84 |
| B | SER153 |
| B | HOH2136 |
| I | HOH2006 |
| I | HOH2007 |
| I | HOH2008 |
| I | HOH2009 |
| I | HOH2010 |
| I | HOH2011 |
| I | HOH2012 |
| I | HOH2014 |
| I | HOH2015 |
| I | HOH2017 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | HIS57 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER195 | |
| B | GLY196 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER195 | |
| B | GLY193 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| B | GLY196 |
