2C7V

Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate

2C7V の概要

• エントリーDOI: 10.2210/pdb2c7v/pdb
• 分子名称: PTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (6 entities in total)
• 機能のキーワード: pteridine reductase, trypanosomatids, drug resistance, short-chain dehydrogenase/reductase, methotrexate resistance, oxidoreductase
• 由来する生物種: TRYPANOSOMA BRUCEI BRUCEI
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 119980.47

構造登録者

Dawson, A.,Gibellini, F.,Sienkiewicz, N.,Fyfe, P.K.,McLuskey, K.,Fairlamb, A.H.,Hunter, W.N. (登録日: 2005-11-29, 公開日: 2006-09-19, 最終更新日: 2023-12-13)

• 主引用文献: Dawson, A.,Gibellini, F.,Sienkiewicz, N.,Tulloch, L.B.,Fyfe, P.K.,Mcluskey, K.,Fairlamb, A.H.,Hunter, W.N.; Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate; Mol.Microbiol., 61:1457-, 2006; PubMed: 16968221; DOI: 10.1111/J.1365-2958.2006.05332.X

実験手法

X-RAY DIFFRACTION (2.2 Å)