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2C6D

Aurora A kinase activated mutant (T287D) in complex with ADPNP

Summary for 2C6D
Entry DOI10.2210/pdb2c6d/pdb
Related1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6E
DescriptorSERINE/THREONINE-PROTEIN KINASE 6, GLYCEROL, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordsaurora, kinase, mitosis, cancer, cell cycle, transferase, serine/threonine-protein kinase, atp-binding, phosphorylation, nucleotide-binding
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains1
Total formula weight32677.97
Authors
Pauptit, R.A.,Pannifer, A.D.,Breed, J.,McMiken, H.H.J.,Rowsell, S.,Anderson, M. (deposition date: 2005-11-09, release date: 2006-01-11, Last modification date: 2023-12-13)
Primary citationHeron, N.M.,Anderson, M.,Blowers, D.P.,Breed, J.,Eden, J.M.,Green, S.,Hill, G.B.,Johnson, T.,Jung, F.H.,Mcmiken, H.H.J.,Mortlock, A.A.,Pannifer, A.D.,Pauptit, R.A.,Pink, J.,Roberts, N.J.,Rowsell, S.
Sar and Inhibitor Complex Structure Determination of a Novel Class of Potent and Specific Aurora Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 16:1320-, 2006
Cited by
PubMed: 16337122
DOI: 10.1016/J.BMCL.2005.11.053
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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