2C6A

Solution structure of the C4 zinc-finger domain of HDM2

2C6A の概要

• エントリーDOI: 10.2210/pdb2c6a/pdb
• 関連するPDBエントリー: 1RV1 1T4E 1T4F 1YCR 1Z1M 2C6B
• 分子名称: UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION (2 entities in total)
• 機能のキーワード: zinc finger, human mdm2, ligase, phosphorylation, alternative splicing, metal-binding, nuclear protein, proto- oncogene, ubl conjugation pathway, zinc
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 5483.40

構造登録者

Yu, G.W.,Allen, M.D.,Andreeva, A.,Fersht, A.R.,Bycroft, M. (登録日: 2005-11-08, 公開日: 2006-01-04, 最終更新日: 2024-05-15)

主引用文献

Yu, G.W.,Allen, M.D.,Andreeva, A.,Fersht, A.R.,Bycroft, M.
Solution Structure of the C4 Zinc Finger Domain of Hdm2.
Protein Sci., 15:384-, 2006

PubMed Abstract: HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.

PubMed: 16385008
DOI: 10.1110/PS.051927306

実験手法

SOLUTION NMR