2BZS
Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.
Summary for 2BZS
Entry DOI | 10.2210/pdb2bzs/pdb |
Related | 1QR2 1SG0 1ZX1 2QR2 |
Descriptor | NRH DEHYDROGENASE [QUINONE] 2, ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, nqo2, cb1954, fad, flavoprotein, metal-binding, polymorphism, zinc |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 55126.38 |
Authors | Abu Khader, M.M.,Heap, J.T.,De Matteis, C.,Kellam, B.,Doughty, S.W.,Minton, N.,Paoli, M. (deposition date: 2005-08-22, release date: 2005-09-23, Last modification date: 2023-12-13) |
Primary citation | Abu Khader, M.M.,Heap, J.T.,De Matteis, C.,Kellam, B.,Doughty, S.W.,Minton, N.,Paoli, M. Binding of the Anticancer Prodrug Cb1954 to the Activating Enzyme Nqo2 Revealed by the Crystal Structure of Their Complex. J.Med.Chem., 48:7714-, 2005 Cited by PubMed: 16302811DOI: 10.1021/JM050730N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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