2BZS

Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NRH DEHYDROGENASE [QUINONE] 2	polymer	236	26460.0	2	UniProt (P16083) Pfam (PF02525)	HOMO SAPIENS (HUMAN)	NRH QUINONE OXIDO-REDUCTASE TYPE 2, QUINONE REDUCTASE 2, QR2, NRH QUINONE OXIDOREDUCTASE 2
2	C, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, G (A, B)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
4	E, H (A, B)	5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE	non-polymer		252.2	2	Chemie (CB1)
5	I, J (A, B)	water	water		18.0	299	Chemie (HOH)

Sequence modifications

A, B: -5 - 0 (PDB: 2BZS)
A, B: 1 - 230 (UniProt: P16083)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52920.1
Non-Polymers*	Number of molecules	6
	Total formula weight	2206.3
All*	Total formula weight	55126.4

*Water molecules are not included.