2BZS

Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.

2BZS の概要

• エントリーDOI: 10.2210/pdb2bzs/pdb
• 関連するPDBエントリー: 1QR2 1SG0 1ZX1 2QR2
• 分子名称: NRH DEHYDROGENASE [QUINONE] 2, ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, nqo2, cb1954, fad, flavoprotein, metal-binding, polymorphism, zinc
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55126.38

構造登録者

Abu Khader, M.M.,Heap, J.T.,De Matteis, C.,Kellam, B.,Doughty, S.W.,Minton, N.,Paoli, M. (登録日: 2005-08-22, 公開日: 2005-09-23, 最終更新日: 2023-12-13)

• 主引用文献: Abu Khader, M.M.,Heap, J.T.,De Matteis, C.,Kellam, B.,Doughty, S.W.,Minton, N.,Paoli, M.; Binding of the Anticancer Prodrug Cb1954 to the Activating Enzyme Nqo2 Revealed by the Crystal Structure of Their Complex.; J.Med.Chem., 48:7714-, 2005; PubMed: 16302811; DOI: 10.1021/JM050730N

実験手法

X-RAY DIFFRACTION (2 Å)