2BUD
The solution structure of the chromo barrel domain from the males- absent on the first (MOF) protein
Summary for 2BUD
| Entry DOI | 10.2210/pdb2bud/pdb |
| Descriptor | MALES-ABSENT ON THE FIRST PROTEIN (1 entity in total) |
| Functional Keywords | transferase, mof, hat, acetyl-transfer, dosage compensation complex, dcc, royal family, chromodomain like, beta barrel, transferase acyltransferase, metal-binding |
| Biological source | DROSOPHILA MELANOGASTER (FRUIT FLY) |
| Total number of polymer chains | 1 |
| Total formula weight | 10352.49 |
| Authors | Nielsen, P.R.,Nietlispach, D.,Buscaino, A.,Warner, R.J.,Akhtar, A.,Murzin, A.G.,Murzina, N.V.,Laue, E.D. (deposition date: 2005-06-09, release date: 2005-06-24, Last modification date: 2024-05-15) |
| Primary citation | Nielsen, P.R.,Nietlispach, D.,Buscaino, A.,Warner, R.J.,Akhtar, A.,Murzin, A.G.,Murzina, N.V.,Laue, E.D. Structure of the Chromo Barrel Domain from the Mof Acetyltransferase J.Biol.Chem., 280:32326-, 2005 Cited by PubMed Abstract: We report here the structure of the putative chromo domain from MOF, a member of the MYST family of histone acetyltransferases that acetylates histone H4 at Lys-16 and is part of the dosage compensation complex in Drosophila. We found that the structure of this domain is a beta-barrel that is distinct from the alpha + beta fold of the canonical chromo domain. Despite the differences, there are similarities that support an evolutionary relationship between the two domains, and we propose the name "chromo barrel." The chromo barrel domains may be divided into two groups, MSL3-like and MOF-like, on the basis of whether a group of conserved aromatic residues is present or not. The structure suggests that, although the MOF-like domains may have a role in RNA binding, the MSL3-like domains could instead bind methylated residues. The MOF chromo barrel shares a common fold with other chromatin-associated modules, including the MBT-like repeat, Tudor, and PWWP domains. This structural similarity suggests a probable evolutionary pathway from these other modules to the canonical chromo domains (or vice versa) with the chromo barrel domain representing an intermediate structure. PubMed: 15964847DOI: 10.1074/JBC.M501347200 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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