2BT4

Type II Dehydroquinase inhibitor complex

Summary for 2BT4

Entry DOI	10.2210/pdb2bt4/pdb
Related	1D0I 1GTZ 1GU0 1GU1 1V1J
Descriptor	3-DEHYDROQUINATE DEHYDRATASE, (1S,3R,4R,5S)-1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)CYCLOHEXANECARBOXYLIC ACID, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	shikimate pathway, dehydroquinate, lyase, amino-acid biosynthesis, aromatic amino acid biosynthesis
Biological source	STREPTOMYCES COELICOLOR
Total number of polymer chains	12
Total formula weight	206107.30
Authors	Toscano, M.D.,Stewart, K.A.,Coggins, J.R.,Lapthorn, A.J.,Abell, C. (deposition date: 2005-05-26, release date: 2006-02-13, Last modification date: 2023-12-13)
Primary citation	Toscano, M.D.,Stewart, K.A.,Coggins, J.R.,Lapthorn, A.J.,Abell, C. Rational Design of New Bifunctional Inhibitors of Type II Dehydroquinase. Org.Biomol.Chem., 3:3102-, 2005 Cited by PubMed Abstract: Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described. PubMed: 16106291 DOI: 10.1039/B507156A PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation