2BRE

STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90.

2BRE の概要

• エントリーDOI: 10.2210/pdb2bre/pdb
• 関連するPDBエントリー: 1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 2BRC
• 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (3 entities in total)
• 機能のキーワード: chaperone-complex, atp-binding, chaperone, heat shock, inhibitor, multigene family
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• 細胞内の位置: Cytoplasm : P02829
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50272.18

構造登録者

Roe, S.M.,Pearl, L.H.,Prodromou, C. (登録日: 2005-05-04, 公開日: 2005-09-29, 最終更新日: 2023-12-13)

• 主引用文献: Cheung, K.M.,Matthews, T.P.,James, K.,Rowlands, M.G.,Boxall, K.J.,Sharp, S.Y.,Maloney, A.,Roe, S.M.,Prodromou, C.,Pearl, L.H.,Aherne, G.W.,McDonald, E.,Workman, P.; The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.; Bioorg. Med. Chem. Lett., 15:3338-3343, 2005; PubMed: 15955698; DOI: 10.1016/j.bmcl.2005.05.046

実験手法

X-RAY DIFFRACTION (2 Å)