2BKK

Crystal structure of Aminoglycoside Phosphotransferase APH(3')-IIIa in complex with the inhibitor AR_3a

2BKK の概要

• エントリーDOI: 10.2210/pdb2bkk/pdb
• 関連するPDBエントリー: 1J7I 1J7L 1J7U 1K1A 1K1B 1L8T 1L8U 1MJ0 1N0Q 1N0R 2BKG
• 分子名称: AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE, DESIGNED ANKYRIN REPEAT INHIBITOR AR_3A, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: transferase/peptide, transferase-designed protein complex, ankyrin repeat, co-crystallization, inhibitor design, drug design, enzyme inhibition, kinase inhibition, designed repeat protein, antibiotic resistance, atp-binding, kinase, plasmid, transferase, transferase-peptide complex
• 由来する生物種: ENTEROCOCCUS FAECALIS; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 100117.13

構造登録者

Kohl, A.,Amstutz, P.,Parizek, P.,Binz, H.K.,Briand, C.,Capitani, G.,Forrer, P.,Pluckthun, A.,Grutter, M.G. (登録日: 2005-02-16, 公開日: 2005-08-09, 最終更新日: 2023-12-13)

• 主引用文献: Kohl, A.,Amstutz, P.,Parizek, P.,Binz, H.K.,Briand, C.,Capitani, G.,Forrer, P.,Pluckthun, A.,Grutter, M.G.; Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein; Structure, 13:1131-, 2005; PubMed: 16084385; DOI: 10.1016/J.STR.2005.04.020

実験手法

X-RAY DIFFRACTION (2.15 Å)