2BFY

Complex of Aurora-B with INCENP and Hesperadin.

Summary for 2BFY

• Entry DOI: 10.2210/pdb2bfy/pdb
• Related: 2BFX
• Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE, ... (4 entities in total)
• Functional Keywords: transferase, kinase, mitosis, inhibition, transferase complex
• Biological source: XENOPUS LAEVIS (AFRICAN CLAWED FROG); More
• Cellular location: Nucleus: Q6DE08; Chromosome, centromere: O13024
• Total number of polymer chains: 4
• Total formula weight: 78146.49

Authors

Sessa, F.,Mapelli, M.,Ciferri, C.,Tarricone, C.,Areces, L.B.,Schneider, T.R.,Stukenberg, P.T.,Musacchio, A. (deposition date: 2004-12-15, release date: 2005-05-03, Last modification date: 2023-12-13)

• Primary citation: Sessa, F.,Mapelli, M.,Ciferri, C.,Tarricone, C.,Areces, L.B.,Schneider, T.R.,Stukenberg, P.T.,Musacchio, A.; Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin; Mol.Cell, 18:379-, 2005; PubMed: 15866179; DOI: 10.1016/J.MOLCEL.2005.03.031

Experimental method

X-RAY DIFFRACTION (1.8 Å)