2BFD

Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch

2BFD の概要

• エントリーDOI: 10.2210/pdb2bfd/pdb
• 関連するPDBエントリー: 1DTW 1OLS 1OLU 1OLX 1U5B 1V11 1V16 1V1M 1V1R 1WCI 1X7W 1X7X 1X7Y 1X7Z 1X80 2BEU 2BEV 2BEW 2BFB 2BFC 2BFE 2BFF
• 分子名称: 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ... (9 entities in total)
• 機能のキーワード: oxidoreductase, multi-enzyme complex, acylation, oxidative decarboxylation, maple syrup urine disease, thiamine diphosphate, phosphorylation, conformational switch
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84102.37

構造登録者

Machius, M.,Wynn, R.M.,Chuang, J.L.,Tomchick, D.R.,Brautigam, C.A.,Chuang, D.T. (登録日: 2004-12-06, 公開日: 2006-02-16, 最終更新日: 2023-12-13)

• 主引用文献: Machius, M.,Wynn, R.M.,Chuang, J.L.,Li, J.,Kluger, R.,Yu, D.,Tomchick, D.R.,Brautigam, C.A.,Chuang, D.T.; A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.; Structure, 14:287-, 2006; PubMed: 16472748; DOI: 10.1016/J.STR.2005.10.009

実験手法

X-RAY DIFFRACTION (1.39 Å)