2BEE
Complex Between Paromomycin derivative JS4 and the 16S-Rrna A Site
Summary for 2BEE
Entry DOI | 10.2210/pdb2bee/pdb |
Related | 1J7T 2BE0 2ESI 2ESJ |
Descriptor | 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-4-(2-(3-AMINOPROPYLAMINO)ETHOXY)-5-((1R,2R,3S,5R,6S)-3,5-DIAM INO-2-((2S,3R,4R,5S,6R)-3-AMINO-4,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-( HYDROXYMETHYL)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL (3 entities in total) |
Functional Keywords | rna-aminoglycoside interactions, a site, uou pairs, aa bulges, rna-antibiotic complex, rna/antibiotic |
Biological source | Streptomyces rimosus subsp. paromomycinus |
Total number of polymer chains | 2 |
Total formula weight | 15528.10 |
Authors | Francois, B.,Westhof, E. (deposition date: 2005-10-24, release date: 2005-12-20, Last modification date: 2024-03-13) |
Primary citation | Francois, B.,Szychowski, J.,Adhikari, S.S.,Pachamuthu, K.,Swayze, E.E.,Griffey, R.H.,Migawa, M.T.,Westhof, E.,Hanessian, S. Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site ANGEW.CHEM.INT.ED.ENGL., 43:6735-6738, 2004 Cited by PubMed: 15593140DOI: 10.1002/anie.200462092 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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