Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin

Summary for 2BE5

Related1IW7 1SMY 2A6E 2A69 2A68 2A6H
DescriptorDNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (9 entities in total)
Functional Keywordsrna polymerase holoenzyme, tagetitoxin, antibiotic, transcription regulation, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase
Biological sourceThermus thermophilus
Total number of polymer chains12
Total molecular weight854462.43
Primary citation
Vassylyev, D.G.,Svetlov, V.,Vassylyeva, M.N.,Perederina, A.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Artsimovitch, I.
Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12:1086-1093, 2005
PubMed: 16273103 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb1015
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.272614.3%23.2%32.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report