2BE5

Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin

2BE5 の概要

• エントリーDOI: 10.2210/pdb2be5/pdb
• 関連するPDBエントリー: 1IW7 1SMY 2A68 2A69 2A6E 2A6H
• 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (9 entities in total)
• 機能のキーワード: rna polymerase holoenzyme, tagetitoxin, antibiotic, transcription regulation, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase
• 由来する生物種: Thermus thermophilus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 854462.43

構造登録者

Vassylyev, D.G.,Svetlov, V.,Vassylyeva, M.N.,Perederina, A.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Artsimovitch, I.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2005-10-22, 公開日: 2005-11-08, 最終更新日: 2023-08-23)

• 主引用文献: Vassylyev, D.G.,Svetlov, V.,Vassylyeva, M.N.,Perederina, A.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Artsimovitch, I.; Structural basis for transcription inhibition by tagetitoxin; Nat.Struct.Mol.Biol., 12:1086-1093, 2005; PubMed: 16273103; DOI: 10.1038/nsmb1015

実験手法

X-RAY DIFFRACTION (2.4 Å)