2BCT

THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN

Summary for 2BCT

• Entry DOI: 10.2210/pdb2bct/pdb
• Descriptor: BETA-CATENIN (1 entity in total)
• Functional Keywords: armadillo repeat, beta-catenin, structural protein
• Biological source: Mus musculus (house mouse)
• Cellular location: Cytoplasm: Q02248
• Total number of polymer chains: 1
• Total formula weight: 56314.34

Authors

Huber, A.H.,Nelson, W.J.,Weis, W.I. (deposition date: 1997-07-30, release date: 1997-10-15, Last modification date: 2024-05-22)

Primary citation

Huber, A.H.,Nelson, W.J.,Weis, W.I.
Three-dimensional structure of the armadillo repeat region of beta-catenin.
Cell(Cambridge,Mass.), 90:871-882, 1997

PubMed Abstract: Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.

PubMed: 9298899
DOI: 10.1016/S0092-8674(00)80352-9

Experimental method

X-RAY DIFFRACTION (2.9 Å)